{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Douglas EJA"],"pubmed_abstract":["New therapeutic options are urgently required for the treatment of <i>Staphylococcus aureus</i> infections. Accordingly, we sought to exploit the vulnerability of <i>S. aureus</i> to naturally occurring polyamines. We have developed and tested the anti-staphylococcal activity of three novel linear polyamines based on spermine and norspermine. Using a panel of genetically distinct and clinically relevant multidrug resistant <i>S. aureus</i> isolates, including the polyamine resistant USA300 strain LAC, compound AHA-1394 showed a greater than 128-fold increase in inhibition against specific <i>S. aureus</i> strains compared to the most active natural polyamine. Furthermore, we show that AHA-1394 has superior biofilm prevention and biofilm dispersal properties compared to natural polyamines w"],"journal":["Frontiers in microbiology"],"pagination":["948343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9441809"],"repository":["biostudies-literature"],"pubmed_title":["Antibacterial activity of novel linear polyamines against <i>Staphylococcus aureus</i>."],"pmcid":["PMC9441809"],"pubmed_authors":["Li S","Woodman TJ","Alkhzem AH","Wonfor T","Laabei M","Douglas EJA","Blagbrough IS"],"additional_accession":[]},"is_claimable":false,"name":"Antibacterial activity of novel linear polyamines against <i>Staphylococcus aureus</i>.","description":"New therapeutic options are urgently required for the treatment of <i>Staphylococcus aureus</i> infections. Accordingly, we sought to exploit the vulnerability of <i>S. aureus</i> to naturally occurring polyamines. We have developed and tested the anti-staphylococcal activity of three novel linear polyamines based on spermine and norspermine. Using a panel of genetically distinct and clinically relevant multidrug resistant <i>S. aureus</i> isolates, including the polyamine resistant USA300 strain LAC, compound AHA-1394 showed a greater than 128-fold increase in inhibition against specific <i>S. aureus</i> strains compared to the most active natural polyamine. Furthermore, we show that AHA-1394 has superior biofilm prevention and biofilm dispersal properties compared to natural polyamines w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T18:44:07.108Z","creation":"2025-04-05T10:59:26.533Z"},"accession":"S-EPMC9441809","cross_references":{"pubmed":["36071957"],"doi":["10.3389/fmicb.2022.948343"]}}