{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(8)"],"submitter":["Ju M"],"pubmed_abstract":["<h4>Background</h4>Trimethoprim/sulfamethoxazole (TMP/SMZ) is widely used in various clinical settings. Studies have revealed that it may cause acute kidney injury (AKI) in adults. However, the correlation between the use of TMP/SMZ and renal injury in pediatric patients is still unclear. This study aimed to identify the impact of TMP/SMZ on the occurrence of AKI in children.<h4>Methods</h4>A retrospective observational study was conducted using data of patients treated with TMP/SMZ from the Paediatric Intensive Care clinical database. A newly developed criterion was used for the diagnosis of AKI, and univariate and multiple logistic regression analyses were performed to identify the risk factors of TMP/SMZ-related renal injury.<h4>Results</h4>A total of 113 patients were included. The pre"],"journal":["Translational pediatrics"],"pagination":["1285-1291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9442208"],"repository":["biostudies-literature"],"pubmed_title":["Prevalence and risk factors of trimethoprim/sulfamethoxazole-related acute kidney injury in pediatric patients: an observational study from a public database."],"pmcid":["PMC9442208"],"pubmed_authors":["Qian Y","Lin D","Zheng M","Ju M","Yuan J"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence and risk factors of trimethoprim/sulfamethoxazole-related acute kidney injury in pediatric patients: an observational study from a public database.","description":"<h4>Background</h4>Trimethoprim/sulfamethoxazole (TMP/SMZ) is widely used in various clinical settings. Studies have revealed that it may cause acute kidney injury (AKI) in adults. However, the correlation between the use of TMP/SMZ and renal injury in pediatric patients is still unclear. This study aimed to identify the impact of TMP/SMZ on the occurrence of AKI in children.<h4>Methods</h4>A retrospective observational study was conducted using data of patients treated with TMP/SMZ from the Paediatric Intensive Care clinical database. A newly developed criterion was used for the diagnosis of AKI, and univariate and multiple logistic regression analyses were performed to identify the risk factors of TMP/SMZ-related renal injury.<h4>Results</h4>A total of 113 patients were included. The pre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T12:25:15.352Z","creation":"2024-11-20T07:55:27.861Z"},"accession":"S-EPMC9442208","cross_references":{"pubmed":["36072532"],"doi":["10.21037/tp-21-600"]}}