biostudies-literatureUnknown11(8)Ju M<h4>Background</h4>Trimethoprim/sulfamethoxazole (TMP/SMZ) is widely used in various clinical settings. Studies have revealed that it may cause acute kidney injury (AKI) in adults. However, the correlation between the use of TMP/SMZ and renal injury in pediatric patients is still unclear. This study aimed to identify the impact of TMP/SMZ on the occurrence of AKI in children.<h4>Methods</h4>A retrospective observational study was conducted using data of patients treated with TMP/SMZ from the Paediatric Intensive Care clinical database. A newly developed criterion was used for the diagnosis of AKI, and univariate and multiple logistic regression analyses were performed to identify the risk factors of TMP/SMZ-related renal injury.<h4>Results</h4>A total of 113 patients were included. The preTranslational pediatrics1285-1291https://www.ebi.ac.uk/biostudies/studies/S-EPMC9442208biostudies-literaturePrevalence and risk factors of trimethoprim/sulfamethoxazole-related acute kidney injury in pediatric patients: an observational study from a public database.PMC9442208Qian YLin DZheng MJu MYuan JfalsePrevalence and risk factors of trimethoprim/sulfamethoxazole-related acute kidney injury in pediatric patients: an observational study from a public database.<h4>Background</h4>Trimethoprim/sulfamethoxazole (TMP/SMZ) is widely used in various clinical settings. Studies have revealed that it may cause acute kidney injury (AKI) in adults. However, the correlation between the use of TMP/SMZ and renal injury in pediatric patients is still unclear. This study aimed to identify the impact of TMP/SMZ on the occurrence of AKI in children.<h4>Methods</h4>A retrospective observational study was conducted using data of patients treated with TMP/SMZ from the Paediatric Intensive Care clinical database. A newly developed criterion was used for the diagnosis of AKI, and univariate and multiple logistic regression analyses were performed to identify the risk factors of TMP/SMZ-related renal injury.<h4>Results</h4>A total of 113 patients were included. The pre2022-01-01T00:00:00Z2022 Aug2025-04-04T12:25:15.352Z2024-11-20T07:55:27.861ZS-EPMC94422083607253210.21037/tp-21-600