biostudies-literatureUnknown69(3)Nguyen M<h4>Introduction</h4>Paediatric patients (individuals below 18 years of age) requiring cranial-spinal irradiation (CSI) at our institution are commonly planned and treated using a three isocentre (3-ISO) volumetric modulated arc therapy (VMAT) technique. A modified two isocentre (2-ISO) VMAT technique was investigated with the aim to improve workflow and reduce planning and treatment time.<h4>Methods</h4>Five CSI paediatric patients previously treated with a 3-ISO VMAT technique were retrospectively replanned using a 2-ISO VMAT technique. The 2-ISO VMAT plans were reviewed and approved by a radiation oncologist (RO) before undergoing patient-specific quality assurance (QA) procedures, performed by a radiation oncology medical physicist (ROMP). Planning target volume (PTV) coverage, organ-aJournal of medical radiation sciences357-366https://www.ebi.ac.uk/biostudies/studies/S-EPMC9442318biostudies-literatureModified volumetric modulated arc therapy technique with reduced planning and treatment time for craniospinal irradiation utilising two isocentres.PMC9442318Sim LPullar ACheuk RGibbs ADang TDeegan LHargrave CNguyen MHenry KJones SfalseModified volumetric modulated arc therapy technique with reduced planning and treatment time for craniospinal irradiation utilising two isocentres.<h4>Introduction</h4>Paediatric patients (individuals below 18 years of age) requiring cranial-spinal irradiation (CSI) at our institution are commonly planned and treated using a three isocentre (3-ISO) volumetric modulated arc therapy (VMAT) technique. A modified two isocentre (2-ISO) VMAT technique was investigated with the aim to improve workflow and reduce planning and treatment time.<h4>Methods</h4>Five CSI paediatric patients previously treated with a 3-ISO VMAT technique were retrospectively replanned using a 2-ISO VMAT technique. The 2-ISO VMAT plans were reviewed and approved by a radiation oncologist (RO) before undergoing patient-specific quality assurance (QA) procedures, performed by a radiation oncology medical physicist (ROMP). Planning target volume (PTV) coverage, organ-a2022-01-01T00:00:00Z2022 Sep2025-04-20T00:39:25.462Z2025-04-20T00:39:25.462ZS-EPMC94423183546019910.1002/jmrs.582