{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18"],"submitter":["Barbosa YCM"],"pubmed_abstract":["The broad application of 1<i>H</i>-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular <i>N</i>-arylation of in situ-generated or isolated <i>o</i>-haloarylhydrazones. Such methods mainly start from <i>o</i>-bromo derivatives due to the better yield observed when compared to those obtained from <i>o</i>-chloroarylhydrazones. However, the <i>o</i>-chloroarylaldehydes and <i>o</i>-chloroarylketones used to prepare the arylhydrazones are more commercially available and less expensive than brominated analogs. Seeking to cover a lack in the literature, this work reports a convenient protocol for the synthesis of <i>N</i>-phenyl- and <i>N</i>-thiazolyl-1<i>H</i>-indazoles by copper-c"],"journal":["Beilstein journal of organic chemistry"],"pagination":["1079-1087"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9443352"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of <i>N</i>-phenyl- and <i>N</i>-thiazolyl-1<i>H</i>-indazoles by copper-catalyzed intramolecular <i>N</i>-arylation of <i>ortho</i>-chlorinated arylhydrazones."],"pmcid":["PMC9443352"],"pubmed_authors":["de Pereira CMP","Pizzuti L","Paveglio GC","Moura S","Schwalm CS","Barbosa YCM","Casagrande GA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of <i>N</i>-phenyl- and <i>N</i>-thiazolyl-1<i>H</i>-indazoles by copper-catalyzed intramolecular <i>N</i>-arylation of <i>ortho</i>-chlorinated arylhydrazones.","description":"The broad application of 1<i>H</i>-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular <i>N</i>-arylation of in situ-generated or isolated <i>o</i>-haloarylhydrazones. Such methods mainly start from <i>o</i>-bromo derivatives due to the better yield observed when compared to those obtained from <i>o</i>-chloroarylhydrazones. However, the <i>o</i>-chloroarylaldehydes and <i>o</i>-chloroarylketones used to prepare the arylhydrazones are more commercially available and less expensive than brominated analogs. Seeking to cover a lack in the literature, this work reports a convenient protocol for the synthesis of <i>N</i>-phenyl- and <i>N</i>-thiazolyl-1<i>H</i>-indazoles by copper-c","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-06-01T00:33:47.733Z","creation":"2024-11-13T06:02:55.599Z"},"accession":"S-EPMC9443352","cross_references":{"pubmed":["36105728"],"doi":["10.3762/bjoc.18.110"]}}