{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Xie G"],"funding":["National Natural Science Foundation of China","Natural Science Foundation of Hunan Province"],"pubmed_abstract":["Qiwei Baizhu Powder (QWBZP) is a traditional Chinese medicine formula for treating diarrhea induced by various causes. It elicits an anti-diarrheal effect by regulating the gut microbiota (diversity, structure, and abundance). However, the contribution of different components in the QWBZP decoction to this effect remains unclear. In this study, we used the QWBZP decoction as a reference standard to investigate the effects of total glycosides (TGs) extracted from QWBZP decoction on the gut microbiota and bile acid metabolism in mice with antibiotic-associated diarrhea (AAD). The results of 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) analysis showed that the effect of total glycosides of Qiwei Baizhu Powder (QWBZP-TG) on specific intestinal bacteria and bile "],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["945263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9444044"],"repository":["biostudies-literature"],"pubmed_title":["Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder <i>via</i> regulating gut microbiota and bile acids."],"pmcid":["PMC9444044"],"pubmed_authors":["Peng X","Xie G","Deng N","Tan Z","Zhang S","Zheng T"],"additional_accession":[]},"is_claimable":false,"name":"Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder <i>via</i> regulating gut microbiota and bile acids.","description":"Qiwei Baizhu Powder (QWBZP) is a traditional Chinese medicine formula for treating diarrhea induced by various causes. It elicits an anti-diarrheal effect by regulating the gut microbiota (diversity, structure, and abundance). However, the contribution of different components in the QWBZP decoction to this effect remains unclear. In this study, we used the QWBZP decoction as a reference standard to investigate the effects of total glycosides (TGs) extracted from QWBZP decoction on the gut microbiota and bile acid metabolism in mice with antibiotic-associated diarrhea (AAD). The results of 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) analysis showed that the effect of total glycosides of Qiwei Baizhu Powder (QWBZP-TG) on specific intestinal bacteria and bile ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-29T16:11:27.812Z","creation":"2025-04-06T01:50:38.551Z"},"accession":"S-EPMC9444044","cross_references":{"pubmed":["36072221"],"doi":["10.3389/fcimb.2022.945263"]}}