{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khoja L"],"funding":["NCI NIH HHS"],"pagination":["195-201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9444325"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["164(1)"],"pubmed_abstract":["<h4>Objective</h4>To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association.<h4>Methods</h4>We conducted a pooled analysis of self-reported data from 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC). Women with (n = 5350) and without ovarian cancer (n = 7544) who never used HT or exclusively used either estrogen-only therapy (ET) or estrogen+progestin therapy (EPT) were included. Risk of invasive epithelial ovarian cancer adjusted for duration of ET and EPT use and stratified on history of endometriosis was determined using odds ratios (ORs) with 95% confidence intervals (CIs).<h4>Results</h4>Overall and among women without endometriosis, there was a positive assoc"],"journal":["Gynecologic oncology"],"pubmed_title":["Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association."],"pmcid":["PMC9444325"],"funding_grant_id":["R01 CA076016","R01 CA074850","P30 CA008748","R01 CA080742","P30 CA046592","R03 CA115195","R03 CA113148","R01 CA054419","N01 PC067006","P30 CA014089","R01 CA063113","N01 CN025403","R01 CA087538","R01 CA063678","P50 CA105009","R01 CA058598","N01 PC067010","R01 CA058860","P01 CA017054","R01 CA112523","N01 CN25524"],"pubmed_authors":["Fortner RT","Hanley GE","Anton-Culver H","Webb PM","Weber RP","Terry KL","Lee AW","Doherty JA","Mukherjee B","Khoja L","Jensen A","Pike MC","Cho K","McLean K","Harris HR","Moysich K","Schildkraut JM","Ziogas A","Chang-Claude J","Australian Ovarian Cancer Study Group","Cramer D","Risch H","Jordan SJ","Goodman MT","Modugno F","Wu AH","Phung MT","Muthukumar A","Pearce CL","Kjaer SK","Berchuck A"],"additional_accession":[]},"is_claimable":false,"name":"Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.","description":"<h4>Objective</h4>To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association.<h4>Methods</h4>We conducted a pooled analysis of self-reported data from 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC). Women with (n = 5350) and without ovarian cancer (n = 7544) who never used HT or exclusively used either estrogen-only therapy (ET) or estrogen+progestin therapy (EPT) were included. Risk of invasive epithelial ovarian cancer adjusted for duration of ET and EPT use and stratified on history of endometriosis was determined using odds ratios (ORs) with 95% confidence intervals (CIs).<h4>Results</h4>Overall and among women without endometriosis, there was a positive assoc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-19T18:08:42.665Z","creation":"2025-04-19T18:08:42.665Z"},"accession":"S-EPMC9444325","cross_references":{"pubmed":["34776242"],"doi":["10.1016/j.ygyno.2021.10.088"]}}