{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nakayama Y"],"funding":["NHLBI NIH HHS"],"pagination":["510-527"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9444972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["131(6)"],"pubmed_abstract":["<h4>Background</h4>An ancient family of arrestin-fold proteins, termed alpha-arrestins, may have conserved roles in regulating nutrient transporter trafficking and cellular metabolism as adaptor proteins. One alpha-arrestin, TXNIP (thioredoxin-interacting protein), is known to regulate myocardial glucose uptake. However, the in vivo role of the related alpha-arrestin, ARRDC4 (arrestin domain-containing protein 4), is unknown.<h4>Methods</h4>We first tested whether interaction with GLUTs (glucose transporters) is a conserved function of the mammalian alpha-arrestins. To define the in vivo function of ARRDC4, we generated and characterized a novel <i>Arrdc4</i> knockout (KO) mouse model. We then analyzed the molecular interaction between arrestin domains and the basal GLUT1.<h4>Results</h4>A"],"journal":["Circulation research"],"pubmed_title":["Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart."],"pmcid":["PMC9444972"],"funding_grant_id":["R01 HL130861","R01 HL166620"],"pubmed_authors":["Patwari P","Mukai N","Nakayama Y","Kreitzer G","Yoshioka J"],"additional_accession":[]},"is_claimable":false,"name":"Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.","description":"<h4>Background</h4>An ancient family of arrestin-fold proteins, termed alpha-arrestins, may have conserved roles in regulating nutrient transporter trafficking and cellular metabolism as adaptor proteins. One alpha-arrestin, TXNIP (thioredoxin-interacting protein), is known to regulate myocardial glucose uptake. However, the in vivo role of the related alpha-arrestin, ARRDC4 (arrestin domain-containing protein 4), is unknown.<h4>Methods</h4>We first tested whether interaction with GLUTs (glucose transporters) is a conserved function of the mammalian alpha-arrestins. To define the in vivo function of ARRDC4, we generated and characterized a novel <i>Arrdc4</i> knockout (KO) mouse model. We then analyzed the molecular interaction between arrestin domains and the basal GLUT1.<h4>Results</h4>A","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-28T14:15:45.443Z","creation":"2024-11-20T03:03:38.407Z"},"accession":"S-EPMC9444972","cross_references":{"pubmed":["35950500"],"doi":["10.1161/CIRCRESAHA.122.321351","10.1161/circresaha.122.321351"]}}