{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li JP"],"funding":["Youth Science and Technology Project of Suzhou","Key Laboratory in Science and Technology Development Project of Suzhou","Peak Academic Talent Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine","Zhejiang Traditional Chinese Medicine Administration","Science and Technology Project of Affiliated Hospital of Nanjing University of Chinese Medicine","Three-Side Innovation Projects for Aquaculture in Jiangsu Province","Advantageous Disciplines Program of Nanjing University of Chinese Medicine","Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China"],"pagination":["76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9446847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["<h4>Background</h4>Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic state of the tumor. The cytochrome c oxidase (COX) subunit is crucial to the mitochondrial respiratory chain.<h4>Methods</h4>We investigated the potential oncogenic role of COX subunit 4 isoform 2 gene (COX4I2) in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and COX regression analysis to examine whether COX4I2 overexpression can predict colorectal cancer (CRC) prognosis. The association of COX4I2 levels with clinical features and its biological actions were evaluated both in vitro and in vivo.<h4>Results</h4>Our analysis showed tha"],"journal":["Cellular & molecular biology letters"],"pubmed_title":["Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC."],"pmcid":["PMC9446847"],"funding_grant_id":["Y2020CX62","SYSD2019006","ZJGQNKJ202036","No. KJXW2019059","ZYX03KF019","y2021rc19","BE2019771","ZYX03KF022","KYCX21-1677"],"pubmed_authors":["Zou X","Liu YJ","Li JP","Zeng SH","Chen YG","Gao HJ"],"additional_accession":[]},"is_claimable":false,"name":"Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC.","description":"<h4>Background</h4>Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic state of the tumor. The cytochrome c oxidase (COX) subunit is crucial to the mitochondrial respiratory chain.<h4>Methods</h4>We investigated the potential oncogenic role of COX subunit 4 isoform 2 gene (COX4I2) in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and COX regression analysis to examine whether COX4I2 overexpression can predict colorectal cancer (CRC) prognosis. The association of COX4I2 levels with clinical features and its biological actions were evaluated both in vitro and in vivo.<h4>Results</h4>Our analysis showed tha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-27T11:20:20.854Z","creation":"2024-11-06T07:25:43.433Z"},"accession":"S-EPMC9446847","cross_references":{"pubmed":["36064310"],"doi":["10.1186/s11658-022-00380-2"]}}