biostudies-literatureBent ANCI NIH HHSNIH5449-5451https://www.ebi.ac.uk/biostudies/studies/S-EPMC9447989biostudies-literatureUnknown27(20)Circulating tumor DNA (ctDNA) has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. Here, we discuss studies that evaluate the ability of plasma-only ctDNA assays to detect minimal residual disease and the potential benefit of integration of methylation into ctDNA assays.<i>See related articles by Parikh et al., p. 5586 and Taieb et al., p. 5638</i>.Clinical cancer research : an official journal of the American Association for Cancer ResearchGoing with the Flow: The Promise of Plasma-Only Circulating Tumor DNA Assays.PMC9447989R01CA184843R01CA218230R01 CA218230P30CA16672P50CA221707P50 CA221707Kopetz SBent AfalseGoing with the Flow: The Promise of Plasma-Only Circulating Tumor DNA Assays.Circulating tumor DNA (ctDNA) has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. Here, we discuss studies that evaluate the ability of plasma-only ctDNA assays to detect minimal residual disease and the potential benefit of integration of methylation into ctDNA assays.<i>See related articles by Parikh et al., p. 5586 and Taieb et al., p. 5638</i>.2021-01-01T00:00:00Z2021 Oct2025-05-29T16:11:47.686Z2025-04-04T09:32:29.589ZS-EPMC94479893438960710.1158/1078-0432.CCR-21-218110.1158/1078-0432.ccr-21-2181