biostudies-literatureBotty van den Bruele ANational Cancer InstituteNCI NIH HHS307-315https://www.ebi.ac.uk/biostudies/studies/S-EPMC9448355biostudies-literatureUnknown189(2)<h4>Purpose</h4>HER2 +- amplified breast cancer patients derive benefit from treatment with anti-HER2-targeted therapy. Though adjuvant treatment is based on final pathology, decisions regarding neoadjuvant chemotherapy are made in the preoperative setting with imaging playing a key role in staging. We examined the accuracy of pre-operative imaging in determining pathological tumor size  (pT) in patients undergoing upfront surgery.<h4>Methods</h4>Early (cT1-T2N0) HER2 + breast cancer patients who underwent upfront surgery between 2015 and 2016 were identified from a prospective institutional database. We compared data for both clinical and final pathologic stage. Only those who underwent magnetic resonance imaging (MRI), mammography, and ultrasound in the preoperative setting were includedBreast cancer research and treatmentDoes preoperative MRI accurately stratify early-stage HER2 + breast cancer patients to upfront surgery vs neoadjuvant chemotherapy?PMC9448355P30 CA008748Hogan MPFornier MNBotty van den Bruele AJaved-Tayyab SMorrow MLe TSevilimedu VFerraro ESacchini VfalseDoes preoperative MRI accurately stratify early-stage HER2 + breast cancer patients to upfront surgery vs neoadjuvant chemotherapy?<h4>Purpose</h4>HER2 +- amplified breast cancer patients derive benefit from treatment with anti-HER2-targeted therapy. Though adjuvant treatment is based on final pathology, decisions regarding neoadjuvant chemotherapy are made in the preoperative setting with imaging playing a key role in staging. We examined the accuracy of pre-operative imaging in determining pathological tumor size  (pT) in patients undergoing upfront surgery.<h4>Methods</h4>Early (cT1-T2N0) HER2 + breast cancer patients who underwent upfront surgery between 2015 and 2016 were identified from a prospective institutional database. We compared data for both clinical and final pathologic stage. Only those who underwent magnetic resonance imaging (MRI), mammography, and ultrasound in the preoperative setting were included2021-01-01T00:00:00Z2021 Sep2025-05-29T16:11:23.199Z2025-04-06T01:48:26.535ZS-EPMC94483553426336610.1007/s10549-021-06331-3