{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Su X"],"pubmed_abstract":["Brucellosis is a zoonotic disease caused by Brucella abortus. An efficient immune response is crucial for curing brucellosis. The inflammasome plays a significant role in the immune response. It is unclear which inflammasome is active in acute and chronic brucellosis and how its levels relate to inflammatory cytokines. A total of 40 patients with acute or chronic brucellosis and 20 healthy volunteers had peripheral blood samples collected. The expression levels of AIM2, NLRP3, ASC, and Caspase-1 were determined by a real-time polymerase chain reaction from RNA and serum samples, and IL-1β, IL-18, and IFN-γ were measured by enzyme-linked immunosorbent assay. In the acute brucellosis group, AIM2 expression was significantly higher, while ACS expression was significantly lower than that of he"],"journal":["Scientific reports"],"pagination":["15123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9448728"],"repository":["biostudies-literature"],"pubmed_title":["Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis."],"pmcid":["PMC9448728"],"pubmed_authors":["Zhao S","Su X","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis.","description":"Brucellosis is a zoonotic disease caused by Brucella abortus. An efficient immune response is crucial for curing brucellosis. The inflammasome plays a significant role in the immune response. It is unclear which inflammasome is active in acute and chronic brucellosis and how its levels relate to inflammatory cytokines. A total of 40 patients with acute or chronic brucellosis and 20 healthy volunteers had peripheral blood samples collected. The expression levels of AIM2, NLRP3, ASC, and Caspase-1 were determined by a real-time polymerase chain reaction from RNA and serum samples, and IL-1β, IL-18, and IFN-γ were measured by enzyme-linked immunosorbent assay. In the acute brucellosis group, AIM2 expression was significantly higher, while ACS expression was significantly lower than that of he","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-27T01:07:42.154Z","creation":"2025-04-06T18:10:10.136Z"},"accession":"S-EPMC9448728","cross_references":{"pubmed":["36068262"],"doi":["10.1038/s41598-022-19398-9"]}}