{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Basaia S"],"funding":["Ministero della Salute","Ministero della Salute (Ministry of Health, Italy)","Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (Ministry of Education, Science and Technological Development of the Republic of Serbia)","Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja"],"pagination":["113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9448730"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the disease that TD patients have a potentiality of converting into. This study investigated functional alterations within the cerebro-cerebellar system in PD-TD and PD-PIGD patients using stepwise functional connectivity (SFC) analysis and identified neuroimaging features that predict TD to PIGD conversion. Thirty-two PD-TD, 26 PD-PIGD patients and 60 healthy controls performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). Four-year clinical follow-up data were available for 28 PD-TD patients, who were classified in 10 converters (cTD-PD) and 18 non-converters (ncTD-PD) to PIGD. The"],"journal":["NPJ Parkinson's disease"],"pubmed_title":["Cerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease."],"pmcid":["PMC9448730"],"funding_grant_id":["RF-2018-12366746","175090"],"pubmed_authors":["Albano L","Filippi M","Balestrino R","Stojkovic T","Sarasso E","Francia A","De Micco R","Stankovic I","Basaia S","Gardoni A","Stefanova E","Markovic V","Kostic VS","Cividini C","Agosta F"],"additional_accession":[]},"is_claimable":false,"name":"Cerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.","description":"Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the disease that TD patients have a potentiality of converting into. This study investigated functional alterations within the cerebro-cerebellar system in PD-TD and PD-PIGD patients using stepwise functional connectivity (SFC) analysis and identified neuroimaging features that predict TD to PIGD conversion. Thirty-two PD-TD, 26 PD-PIGD patients and 60 healthy controls performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). Four-year clinical follow-up data were available for 28 PD-TD patients, who were classified in 10 converters (cTD-PD) and 18 non-converters (ncTD-PD) to PIGD. The","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-27T01:08:06.481Z","creation":"2025-04-06T18:10:22.713Z"},"accession":"S-EPMC9448730","cross_references":{"pubmed":["36068246"],"doi":["10.1038/s41531-022-00377-w"]}}