biostudies-literatureBasaia SMinistero della SaluteMinistero della Salute (Ministry of Health, Italy)Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (Ministry of Education, Science and Technological Development of the Republic of Serbia)Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja113https://www.ebi.ac.uk/biostudies/studies/S-EPMC9448730biostudies-literatureUnknown8(1)Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the disease that TD patients have a potentiality of converting into. This study investigated functional alterations within the cerebro-cerebellar system in PD-TD and PD-PIGD patients using stepwise functional connectivity (SFC) analysis and identified neuroimaging features that predict TD to PIGD conversion. Thirty-two PD-TD, 26 PD-PIGD patients and 60 healthy controls performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). Four-year clinical follow-up data were available for 28 PD-TD patients, who were classified in 10 converters (cTD-PD) and 18 non-converters (ncTD-PD) to PIGD. TheNPJ Parkinson's diseaseCerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.PMC9448730RF-2018-12366746175090Albano LFilippi MBalestrino RStojkovic TSarasso EFrancia ADe Micco RStankovic IBasaia SGardoni AStefanova EMarkovic VKostic VSCividini CAgosta FfalseCerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the disease that TD patients have a potentiality of converting into. This study investigated functional alterations within the cerebro-cerebellar system in PD-TD and PD-PIGD patients using stepwise functional connectivity (SFC) analysis and identified neuroimaging features that predict TD to PIGD conversion. Thirty-two PD-TD, 26 PD-PIGD patients and 60 healthy controls performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). Four-year clinical follow-up data were available for 28 PD-TD patients, who were classified in 10 converters (cTD-PD) and 18 non-converters (ncTD-PD) to PIGD. The2022-01-01T00:00:00Z2022 Sep2025-04-27T01:08:06.481Z2025-04-06T18:10:22.713ZS-EPMC94487303606824610.1038/s41531-022-00377-w