biostudies-literatureUnknown127Tiozon RJNCGIARDepartment of Agriculture Cooperation and Farmers WelfareBiotechnology and Biological Sciences Research Council<h4>Background</h4>Whole grain cereals are a good source of nutrients. Several cutting-edge metabolomic platforms have been deployed to identify various phenolic compounds and enhance cereal bioactive bioavailability. A diet rich in cereal phenolics may modify the microbial composition, support gut homeostasis, and increase gut health, thereby lowering the risk of non-communicable illness.<h4>Scope and approach</h4>In this work, we reviewed current metabolomic breakthroughs in cereal phenolic profiling and their effects on human health via gut microbiota modulation. We argue that the information presented in this paper will assist in the development of nutritionally superior cereal breeds and functional foods.<h4>Key findings and conclusion</h4>Most cereal grains contain ferulic acid derivTrends in food science & technology14-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC9449372biostudies-literatureMetabolomics based inferences to unravel phenolic compound diversity in cereals and its implications for human gut health.PMC9449372Serrano LMNSartagoda KJDFernie ARSreenivasulu NTiozon RJNfalseMetabolomics based inferences to unravel phenolic compound diversity in cereals and its implications for human gut health.<h4>Background</h4>Whole grain cereals are a good source of nutrients. Several cutting-edge metabolomic platforms have been deployed to identify various phenolic compounds and enhance cereal bioactive bioavailability. A diet rich in cereal phenolics may modify the microbial composition, support gut homeostasis, and increase gut health, thereby lowering the risk of non-communicable illness.<h4>Scope and approach</h4>In this work, we reviewed current metabolomic breakthroughs in cereal phenolic profiling and their effects on human health via gut microbiota modulation. We argue that the information presented in this paper will assist in the development of nutritionally superior cereal breeds and functional foods.<h4>Key findings and conclusion</h4>Most cereal grains contain ferulic acid deriv2022-01-01T00:00:00Z2022 Sep2025-04-05T13:40:59.855Z2025-04-05T13:40:59.855ZS-EPMC94493723609046810.1016/j.tifs.2022.06.011