{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Key R &amp; D projects of Xinjiang Autonomous Region","Taishan Industry Leadership Project","Shandong Post-doctoral Innovation Project","Key R & D projects of Xinjiang Autonomous Region","Natural Science Foundation of Shandong Province","National Natural Science Foundation of China","Special Economic Animal Industry Technology System of Shandong Province","Modern Agro-industry Technology Research system"],"pagination":["1444-1453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9449403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(9)"],"pubmed_abstract":["<h4>Objective</h4>Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism.<h4>Methods</h4>The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively.<h4>Results</h4>It indicated tha"],"journal":["Animal bioscience"],"pubmed_title":["Mechanistic target of rapamycin and an extracellular signaling-regulated kinases 1 and 2 signaling participate in the process of acetate regulating lipid metabolism and hormone-sensitive lipase expression."],"pmcid":["PMC9449403"],"funding_grant_id":["CARS-43-B-1","ZR2021MC043","TSCY20190107","SDAIT-21-16","31972594","2020B01004-1-3"],"pubmed_authors":["Liu Y","Li Y","Fu C","Liu L","Li F"],"additional_accession":[]},"is_claimable":false,"name":"Mechanistic target of rapamycin and an extracellular signaling-regulated kinases 1 and 2 signaling participate in the process of acetate regulating lipid metabolism and hormone-sensitive lipase expression.","description":"<h4>Objective</h4>Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism.<h4>Methods</h4>The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively.<h4>Results</h4>It indicated tha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-28T00:33:53.099Z","creation":"2025-04-06T01:52:13.3Z"},"accession":"S-EPMC9449403","cross_references":{"pubmed":["34727637"],"doi":["10.5713/ab.21.0341"]}}