biostudies-literatureLi YKey R &amp; D projects of Xinjiang Autonomous RegionTaishan Industry Leadership ProjectShandong Post-doctoral Innovation ProjectKey R & D projects of Xinjiang Autonomous RegionNatural Science Foundation of Shandong ProvinceNational Natural Science Foundation of ChinaSpecial Economic Animal Industry Technology System of Shandong ProvinceModern Agro-industry Technology Research system1444-1453https://www.ebi.ac.uk/biostudies/studies/S-EPMC9449403biostudies-literatureUnknown35(9)<h4>Objective</h4>Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism.<h4>Methods</h4>The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively.<h4>Results</h4>It indicated thaAnimal bioscienceMechanistic target of rapamycin and an extracellular signaling-regulated kinases 1 and 2 signaling participate in the process of acetate regulating lipid metabolism and hormone-sensitive lipase expression.PMC9449403CARS-43-B-1ZR2021MC043TSCY20190107SDAIT-21-16319725942020B01004-1-3Liu YLi YFu CLiu LLi FfalseMechanistic target of rapamycin and an extracellular signaling-regulated kinases 1 and 2 signaling participate in the process of acetate regulating lipid metabolism and hormone-sensitive lipase expression.<h4>Objective</h4>Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism.<h4>Methods</h4>The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively.<h4>Results</h4>It indicated tha2022-01-01T00:00:00Z2022 Sep2026-05-28T00:33:53.099Z2025-04-06T01:52:13.3ZS-EPMC94494033472763710.5713/ab.21.0341