{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Sun WJ"],"pubmed_abstract":["Established a model of lipopolysaccharide (LPS)-induced mastitis in mice, pathological sections and myeloperoxidase were used to detect the degree of tissue damage, enzyme-linked immunosorbent assay (ELISA) was performed to detect the expression of pro-inflammatory cytokines, meanwhile fluorescence quantitative PCR experiments were performed to detect the mRNA expression of CD14/TLR4/NF-κB/MAPK signalling pathway, and the faeces of mice were collected for 16S measurement of flora. The results showed that <i>Abrus cantoniensis</i> total flavonoids (ATF) could significantly reduce the damage of LPS on mammary tissue in mice and inhibit the secretion of inflammatory factors such as TNF-α, IL-1β and IL-6. At the mRNA level, ATF inhibited the expression of CD14/TLR4/NF-κB/MAPK pathway and enhan"],"journal":["Frontiers in microbiology"],"pagination":["985529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9449526"],"repository":["biostudies-literature"],"pubmed_title":["Total flavonoids of <i>Abrus cantoniensis</i> inhibit CD14/TLR4/NF-κB/MAPK pathway expression and improve gut microbiota disorders to reduce lipopolysaccharide-induced mastitis in mice."],"pmcid":["PMC9449526"],"pubmed_authors":["Sun WJ","Zhang GY","He LZ","Wu EY","Xu BC","Chen XG","Lv QZ","Wang Y","Hao KY"],"additional_accession":[]},"is_claimable":false,"name":"Total flavonoids of <i>Abrus cantoniensis</i> inhibit CD14/TLR4/NF-κB/MAPK pathway expression and improve gut microbiota disorders to reduce lipopolysaccharide-induced mastitis in mice.","description":"Established a model of lipopolysaccharide (LPS)-induced mastitis in mice, pathological sections and myeloperoxidase were used to detect the degree of tissue damage, enzyme-linked immunosorbent assay (ELISA) was performed to detect the expression of pro-inflammatory cytokines, meanwhile fluorescence quantitative PCR experiments were performed to detect the mRNA expression of CD14/TLR4/NF-κB/MAPK signalling pathway, and the faeces of mice were collected for 16S measurement of flora. The results showed that <i>Abrus cantoniensis</i> total flavonoids (ATF) could significantly reduce the damage of LPS on mammary tissue in mice and inhibit the secretion of inflammatory factors such as TNF-α, IL-1β and IL-6. At the mRNA level, ATF inhibited the expression of CD14/TLR4/NF-κB/MAPK pathway and enhan","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T10:09:17.817Z","creation":"2024-12-04T07:46:32.519Z"},"accession":"S-EPMC9449526","cross_references":{"pubmed":["36090098"],"doi":["10.3389/fmicb.2022.985529"]}}