{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Steinl GK"],"funding":["American Thyroid Association","NCI NIH HHS"],"pagination":["115871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9450481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145"],"pubmed_abstract":["<h4>Background</h4>Bone Mineral Density (BMD) improves after parathyroidectomy (PTX), but data on factors that predict bone recovery are limited. No studies have evaluated if preoperative imaging findings are associated with postoperative change in BMD. We hypothesized that larger, metabolically active glands would be associated with greater increase in BMD after PTX.<h4>Methods</h4>Patients with primary hyperparathyroidism (PHPT) who underwent combined Tc-99m sestamibi and 4D-CT imaging prior to PTX and had pre- and post-operative dual-energy X-ray absorptiometry (DXA) at our institution were considered for inclusion. Retrospectively, data were collected from imaging studies on each parathyroid gland, including estimated weight (using the ellipsoid formula) and contrast enhancement on 4D-"],"journal":["Bone"],"pubmed_title":["Preoperative imaging predicts change in bone mineral density after parathyroidectomy for primary hyperparathyroidism."],"pmcid":["PMC9450481"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["McManus C","Lee JA","Kuo JH","Steinl GK","Yeh R","Walker MD"],"additional_accession":[]},"is_claimable":false,"name":"Preoperative imaging predicts change in bone mineral density after parathyroidectomy for primary hyperparathyroidism.","description":"<h4>Background</h4>Bone Mineral Density (BMD) improves after parathyroidectomy (PTX), but data on factors that predict bone recovery are limited. No studies have evaluated if preoperative imaging findings are associated with postoperative change in BMD. We hypothesized that larger, metabolically active glands would be associated with greater increase in BMD after PTX.<h4>Methods</h4>Patients with primary hyperparathyroidism (PHPT) who underwent combined Tc-99m sestamibi and 4D-CT imaging prior to PTX and had pre- and post-operative dual-energy X-ray absorptiometry (DXA) at our institution were considered for inclusion. Retrospectively, data were collected from imaging studies on each parathyroid gland, including estimated weight (using the ellipsoid formula) and contrast enhancement on 4D-","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-18T15:34:43.573Z","creation":"2025-04-07T02:17:35.075Z"},"accession":"S-EPMC9450481","cross_references":{"pubmed":["33540118"],"doi":["10.1016/j.bone.2021.115871"]}}