biostudies-literatureUnknownde Rooij LPMHUniversity HospitalsEuropean Research CouncilFonds Wetenschappelijk OnderzoekFundamental Clinical MandateERC Research GrantFlemish Supercomputer CenterMethusalem fundingStichting tegen KankerFlemish GovernmentLeuven UniversityHercules Foundation<h4>Aims</h4>SARS-CoV-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the functional relevance of non-vascular cell types (e.g. immune and epithelial cells) in COVID-19 are becoming increasingly evident. However, despite its known contribution to vascular inflammation, recruitment/invasion of immune cells, vascular leakage and perturbed hemostasis in the lungs of severe COVID-19 patients, an in-depth interrogation of the endothelial cell (EC) compartment in lethal COVID-19 is lacking. Moreover, progressive fibrotic lung disease represents one of the complications of COVID-19 pneumonia and ARDS. Analogous features between idiopathic pulmonary fibrosis (IPF) and COVID-19 suggest partial similaCardiovascular researchcvac139https://www.ebi.ac.uk/biostudies/studies/S-EPMC9452154biostudies-literatureThe pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution.PMC94521547137581833317N771883ERC743074Thienpont BMazzone MTruong ACKJacobs WBorri MMenter TCarmeliet PSubramanian ATzankov AVan Raemdonck Dvan Dorpe JBoudewijns RVinckier SAmersfoort JFeys SVerleden SLiesenborghs LDewerchin MSokol LMeta EWauters EWauters JStalder AKPhilips GDendooven AVan Buyten Tde Rooij LPMHGunst JTeuwen LALammens MLambrechts DJansen SKuehnel MEelen GNeyts JVan Mol PWuyts WCeulemans LJSchoonjans LBecker LMRohlenova KBoeckx BGeldhof VLibbrecht SHaslbauer JDDumas SJWeynand BJonigk DfalseThe pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution.<h4>Aims</h4>SARS-CoV-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the functional relevance of non-vascular cell types (e.g. immune and epithelial cells) in COVID-19 are becoming increasingly evident. However, despite its known contribution to vascular inflammation, recruitment/invasion of immune cells, vascular leakage and perturbed hemostasis in the lungs of severe COVID-19 patients, an in-depth interrogation of the endothelial cell (EC) compartment in lethal COVID-19 is lacking. Moreover, progressive fibrotic lung disease represents one of the complications of COVID-19 pneumonia and ARDS. Analogous features between idiopathic pulmonary fibrosis (IPF) and COVID-19 suggest partial simila2022-01-01T00:00:00Z2022 Aug2025-04-04T23:13:48.279Z2025-04-04T23:13:48.279ZS-EPMC94521543599807810.1093/cvr/cvac139