{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(8)"],"submitter":["Zhang X"],"pubmed_abstract":["<h4>Objective</h4>The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).<h4>Methods</h4>Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were dete"],"journal":["American journal of translational research"],"pagination":["5896-5904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9452356"],"repository":["biostudies-literature"],"pubmed_title":["Autophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism."],"pmcid":["PMC9452356"],"pubmed_authors":["Yang N","Shao L","Zhang X","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"Autophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism.","description":"<h4>Objective</h4>The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).<h4>Methods</h4>Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were dete","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T00:33:43.469Z","creation":"2025-04-06T01:52:09.731Z"},"accession":"S-EPMC9452356","cross_references":{"pubmed":["36105056"]}}