biostudies-literatureUnknown14(8)Zhang X<h4>Objective</h4>The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).<h4>Methods</h4>Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were deteAmerican journal of translational research5896-5904https://www.ebi.ac.uk/biostudies/studies/S-EPMC9452356biostudies-literatureAutophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism.PMC9452356Yang NShao LZhang XChen XfalseAutophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism.<h4>Objective</h4>The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).<h4>Methods</h4>Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were dete2022-01-01T00:00:00Z20222026-05-28T00:33:43.469Z2025-04-06T01:52:09.731ZS-EPMC945235636105056