{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yue J"],"funding":["Natural Science Foundation of Inner Mongolia","Ministerio de Ciencia e Innovación","National Natural Science Foundation of China","Inner Mongolia Agricultural University"],"pagination":["1555-1564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9452765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["Proteins of the alkylation B (AlkB) superfamily show RNA demethylase activity removing methyl adducts from N<sup>6</sup> -methyladenosine (m<sup>6</sup> A). m<sup>6</sup> A is a reversible epigenetic mark of RNA that regulates human virus replication but has unclear roles in plant virus infection. We focused on Potyvirus-the largest genus of plant RNA viruses-and report here the identification of AlkB domains within P1 of endive necrotic mosaic virus (ENMV) and an additional virus of a putative novel species within Potyvirus. We show that Nicotiana benthamiana m<sup>6</sup> A levels are reduced by infection of plum pox virus (PPV) and potato virus Y (PVY). The two potyviruses lack AlkB and the results suggest a general involvement of RNA methylation in potyvirus infection and evolution. Me"],"journal":["Molecular plant pathology"],"pubmed_title":["AlkB RNA demethylase homologues and N<sup>6</sup> -methyladenosine are involved in Potyvirus infection."],"pmcid":["PMC9452765"],"funding_grant_id":["NDGCC2016‐23","IJC2019‐039970‐I","PID2020‐114691RB‐I00","2021ZD06","31770165","31860489"],"pubmed_authors":["Zhao M","Pasin F","Chen Y","Wei X","Wang H","Wei Y","Sun Z","Yue J"],"additional_accession":[]},"is_claimable":false,"name":"AlkB RNA demethylase homologues and N<sup>6</sup> -methyladenosine are involved in Potyvirus infection.","description":"Proteins of the alkylation B (AlkB) superfamily show RNA demethylase activity removing methyl adducts from N<sup>6</sup> -methyladenosine (m<sup>6</sup> A). m<sup>6</sup> A is a reversible epigenetic mark of RNA that regulates human virus replication but has unclear roles in plant virus infection. We focused on Potyvirus-the largest genus of plant RNA viruses-and report here the identification of AlkB domains within P1 of endive necrotic mosaic virus (ENMV) and an additional virus of a putative novel species within Potyvirus. We show that Nicotiana benthamiana m<sup>6</sup> A levels are reduced by infection of plum pox virus (PPV) and potato virus Y (PVY). The two potyviruses lack AlkB and the results suggest a general involvement of RNA methylation in potyvirus infection and evolution. Me","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-07-14T15:23:29.85Z","creation":"2025-04-07T08:28:57.911Z"},"accession":"S-EPMC9452765","cross_references":{"pubmed":["35700092"],"doi":["10.1111/mpp.13239"]}}