biostudies-literatureUnknown13Liu X<h4>Background</h4>Obstructive sleep apnea (OSA) is associated with cerebral small vessel disease (CSVD). Nonetheless, whether OSA-risk determined by a simple screening questionnaire or indices quantifying nocturnal hypoxemia other than the conventional apnea-hypopnea index (AHI) by the home sleep apnea test (HSAT) associated with CSVD burden remains uncertain.<h4>Methods</h4>From 2018 to 2021, we recruited patients with transient ischemic attack (TIA)/minor stroke from the Queen Mary Hospital Acute Stroke Unit and TIA/Stroke Outpatient Clinics. Logistic regression models were applied to determine the association of baseline OSA-risk (on STOP-BANG questionnaire) or HSAT-derived indices quantifying nocturnal hypoxemia with global burden/individual markers of CSVD on MRI. Indices included oxFrontiers in neurology956208https://www.ebi.ac.uk/biostudies/studies/S-EPMC9452809biostudies-literatureAssociations of sleep apnea risk and oxygen desaturation indices with cerebral small vessel disease burden in patients with stroke.PMC9452809Liu XMak HKIp MSLau KKLam DCfalseAssociations of sleep apnea risk and oxygen desaturation indices with cerebral small vessel disease burden in patients with stroke.<h4>Background</h4>Obstructive sleep apnea (OSA) is associated with cerebral small vessel disease (CSVD). Nonetheless, whether OSA-risk determined by a simple screening questionnaire or indices quantifying nocturnal hypoxemia other than the conventional apnea-hypopnea index (AHI) by the home sleep apnea test (HSAT) associated with CSVD burden remains uncertain.<h4>Methods</h4>From 2018 to 2021, we recruited patients with transient ischemic attack (TIA)/minor stroke from the Queen Mary Hospital Acute Stroke Unit and TIA/Stroke Outpatient Clinics. Logistic regression models were applied to determine the association of baseline OSA-risk (on STOP-BANG questionnaire) or HSAT-derived indices quantifying nocturnal hypoxemia with global burden/individual markers of CSVD on MRI. Indices included ox2022-01-01T00:00:00Z20222025-04-18T22:41:59.232Z2025-04-07T10:25:32.165ZS-EPMC94528093609087610.3389/fneur.2022.956208