biostudies-literatureUnknown13Rupp T<b>Purpose:</b> Hypoxia is one major environmental factor, supposed to mediate central motor command as well as afferent feedbacks at rest and during exercise. By using a comparison of normobaric (NH) and hypobaric (HH) hypoxia with the same ambient pressure in oxygen, we examined the potential differences on the cerebrovascular and muscular regulation interplay during a self-paced aerobic exercise. <b>Methods:</b> Sixteen healthy subjects performed three cycling time-trials (250 kJ) in three conditions: HH, NH and normobaric normoxia (NN) after 24 h of exposure. Cerebral and muscular oxygenation were assessed by near-infrared spectroscopy, cerebral blood flow by Doppler ultrasound system. Gas exchanges, peripheral oxygen saturation, power output and associated pacing strategies were also Frontiers in physiology893872https://www.ebi.ac.uk/biostudies/studies/S-EPMC9453479biostudies-literatureBrain-muscle interplay during endurance self-paced exercise in normobaric and hypobaric hypoxia.PMC9453479Saugy JJRupp TBourdillon NMillet GPfalseBrain-muscle interplay during endurance self-paced exercise in normobaric and hypobaric hypoxia.<b>Purpose:</b> Hypoxia is one major environmental factor, supposed to mediate central motor command as well as afferent feedbacks at rest and during exercise. By using a comparison of normobaric (NH) and hypobaric (HH) hypoxia with the same ambient pressure in oxygen, we examined the potential differences on the cerebrovascular and muscular regulation interplay during a self-paced aerobic exercise. <b>Methods:</b> Sixteen healthy subjects performed three cycling time-trials (250 kJ) in three conditions: HH, NH and normobaric normoxia (NN) after 24 h of exposure. Cerebral and muscular oxygenation were assessed by near-infrared spectroscopy, cerebral blood flow by Doppler ultrasound system. Gas exchanges, peripheral oxygen saturation, power output and associated pacing strategies were also 2022-01-01T00:00:00Z20222025-04-05T10:25:54.478Z2025-04-05T10:25:54.478ZS-EPMC94534793609139310.3389/fphys.2022.893872