{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(35)"],"submitter":["Iyer MR"],"pubmed_abstract":["We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326."],"journal":["ACS omega"],"pagination":["31612-31620"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9453971"],"repository":["biostudies-literature"],"pubmed_title":["One-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte's Reaction."],"pmcid":["PMC9453971"],"pubmed_authors":["Kundu B","Bhattacharjee P","Rutland N","Iyer MR","Wood CM"],"additional_accession":[]},"is_claimable":false,"name":"One-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte's Reaction.","description":"We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-18T15:35:23.11Z","creation":"2025-04-07T02:21:00.733Z"},"accession":"S-EPMC9453971","cross_references":{"pubmed":["36092569"],"doi":["10.1021/acsomega.2c04816"]}}