biostudies-literatureUnknown7(35)Iyer MRWe report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.ACS omega31612-31620https://www.ebi.ac.uk/biostudies/studies/S-EPMC9453971biostudies-literatureOne-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte's Reaction.PMC9453971Kundu BBhattacharjee PRutland NIyer MRWood CMfalseOne-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte's Reaction.We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.2022-01-01T00:00:00Z2022 Sep2025-04-18T15:35:23.11Z2025-04-07T02:21:00.733ZS-EPMC94539713609256910.1021/acsomega.2c04816