{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(9)"],"submitter":["Wang C"],"pubmed_abstract":["The recently discovered insecticidal protein Mpp75Aa1.1 from Brevibacillus laterosporus is a member of the ETX_MTX family of beta-pore forming proteins (β-PFPs) expressed in genetically modified (GM) maize to control western corn rootworm (WCR; Diabrotica virgifera virgifera LeConte). In this manuscript, bioinformatic analysis establishes that although Mpp75Aa1.1 shares varying degrees of similarity to members of the ETX_MTX2 protein family, it is unlikely to have any allergenic, toxic, or otherwise adverse biological effects. The safety of Mpp75Aa1.1 is further supported by a weight of evidence approach including evaluation of the history of safe use (HOSU) of ETX_MTX2 proteins and Breviballus laterosporus. Comparisons between purified Mpp75Aa1.1 protein and a poly-histidine-tagged (His-t"],"journal":["PloS one"],"pagination":["e0274204"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9455866"],"repository":["biostudies-literature"],"pubmed_title":["Safety assessment of Mpp75Aa1.1, a new ETX_MTX2 protein from Brevibacillus laterosporus that controls western corn rootworm."],"pmcid":["PMC9455866"],"pubmed_authors":["Chen CJ","Milligan JS","Wang C","Tan J","Edrington TC","Visconti NR","Bean GJ","Kessenich CR","Giddings KS","Moar WJ","Luo J","Bowen D","Moore RG","Li B","Ciche T","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Safety assessment of Mpp75Aa1.1, a new ETX_MTX2 protein from Brevibacillus laterosporus that controls western corn rootworm.","description":"The recently discovered insecticidal protein Mpp75Aa1.1 from Brevibacillus laterosporus is a member of the ETX_MTX family of beta-pore forming proteins (β-PFPs) expressed in genetically modified (GM) maize to control western corn rootworm (WCR; Diabrotica virgifera virgifera LeConte). In this manuscript, bioinformatic analysis establishes that although Mpp75Aa1.1 shares varying degrees of similarity to members of the ETX_MTX2 protein family, it is unlikely to have any allergenic, toxic, or otherwise adverse biological effects. The safety of Mpp75Aa1.1 is further supported by a weight of evidence approach including evaluation of the history of safe use (HOSU) of ETX_MTX2 proteins and Breviballus laterosporus. Comparisons between purified Mpp75Aa1.1 protein and a poly-histidine-tagged (His-t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-10T06:21:41.628Z","creation":"2024-11-19T17:05:06.358Z"},"accession":"S-EPMC9455866","cross_references":{"pubmed":["36074780"],"doi":["10.1371/journal.pone.0274204"]}}