biostudies-literatureMichalicha AMedical University of Lublin10084https://www.ebi.ac.uk/biostudies/studies/S-EPMC9456470biostudies-literatureUnknown23(17)Curdlan (β-1,3-glucan), as a biodegradable polymer, is still an underestimated but potentially attractive matrix for the production of dressing materials. However, due to its lack of susceptibility to functionalization, its use is limited. The proposed curdlan modification, using a functional polycatecholamine layer, enables the immobilization of selected oxidoreductases (laccase and peroxidase) on curdlan hydrogel. The following significant changes of biological and mechanical properties of polycatecholamines + oxidoreductases-modified matrices were observed: reduced response of human monocytes in contact with the hydrogels, modulated reaction of human blood, in terms of hemolysis and clot formation, and changed mechanical properties. The lack of toxicity towards human fibroblasts and theInternational journal of molecular sciencesMedical Use of Polycatecholamines + Oxidoreductases-Modified Curdlan Hydrogels-Perspectives.PMC9456470DS 6Stefaniuk DMichalicha AJaszek MPrzekora AMatuszewska ABelcarz AfalseMedical Use of Polycatecholamines + Oxidoreductases-Modified Curdlan Hydrogels-Perspectives.Curdlan (β-1,3-glucan), as a biodegradable polymer, is still an underestimated but potentially attractive matrix for the production of dressing materials. However, due to its lack of susceptibility to functionalization, its use is limited. The proposed curdlan modification, using a functional polycatecholamine layer, enables the immobilization of selected oxidoreductases (laccase and peroxidase) on curdlan hydrogel. The following significant changes of biological and mechanical properties of polycatecholamines + oxidoreductases-modified matrices were observed: reduced response of human monocytes in contact with the hydrogels, modulated reaction of human blood, in terms of hemolysis and clot formation, and changed mechanical properties. The lack of toxicity towards human fibroblasts and the2022-01-01T00:00:00Z2022 Sep2025-04-25T23:40:08.674Z2024-11-06T18:39:53.031ZS-EPMC94564703607748010.3390/ijms231710084