{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren W"],"funding":["Tenth Youth Fund of the First Hospital of Jilin University","Jilin Provincial Department of science and technology"],"pagination":["5609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9457787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(17)"],"pubmed_abstract":["The TDM of voriconazole which exhibits wide inter-individual variability is indispensable for treatment in clinic. In this study, a method that high-performance liquid chromatography tandem mass spectrometry cubed (HPLC-MS<sup>3</sup>) is first built and validated to quantify voriconazole in human plasma. The system is composed of Shimadzu Exion LC<sup>TM</sup> UPLC coupled with a Qtrap 5500 mass spectrometer. The separation of voriconazole is performed on a Poroshell 120 SB-C18 column at a flow rate of 0.8 mL/min remaining 7 min for each sample. The calibration curves are linear in the concentration range of 0.25-20 μg/mL. Intra-day and inter-day accuracies and precisions are within 8.0% at three concentrations, and the recoveries and matrix effect are all within accepted limits. In terms"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Comparison of LC-MS<sup>3</sup> and LC-MRM Method for Quantifying Voriconazole and Its Application in Therapeutic Drug Monitoring of Human Plasma."],"pmcid":["PMC9457787"],"funding_grant_id":["JDYY102019019","20200404167YY"],"pubmed_authors":["Zhang G","Ren W","Zhai T","Huang J","Yin L"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of LC-MS<sup>3</sup> and LC-MRM Method for Quantifying Voriconazole and Its Application in Therapeutic Drug Monitoring of Human Plasma.","description":"The TDM of voriconazole which exhibits wide inter-individual variability is indispensable for treatment in clinic. In this study, a method that high-performance liquid chromatography tandem mass spectrometry cubed (HPLC-MS<sup>3</sup>) is first built and validated to quantify voriconazole in human plasma. The system is composed of Shimadzu Exion LC<sup>TM</sup> UPLC coupled with a Qtrap 5500 mass spectrometer. The separation of voriconazole is performed on a Poroshell 120 SB-C18 column at a flow rate of 0.8 mL/min remaining 7 min for each sample. The calibration curves are linear in the concentration range of 0.25-20 μg/mL. Intra-day and inter-day accuracies and precisions are within 8.0% at three concentrations, and the recoveries and matrix effect are all within accepted limits. In terms","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T18:24:34.949Z","creation":"2025-04-07T06:01:42.933Z"},"accession":"S-EPMC9457787","cross_references":{"pubmed":["36080374"],"doi":["10.3390/molecules27175609"]}}