biostudies-literatureKiki GAABourses de recherche doctorale et postdoctorale « Eugen Ionescu »5445https://www.ebi.ac.uk/biostudies/studies/S-EPMC9457916biostudies-literatureUnknown27(17)<i>Dichrostachys cinerea</i> (L.) Wigth & Arn. (DC) is widely used in traditional medicine against several inflammatory diseases, especially rheumatoid arthritis, because of its antioxidant and anti-inflammatory effects. This study aimed to characterize the polyphenol-rich DC fruit extracts and investigate the analgesic, anti-inflammatory, and antioxidant effects in a rat inflammation model induced by complete Freund's adjuvant (CFA). Water and ethanolic extracts were characterized using liquid chromatography coupled with mass spectrometry (LC-MS), Fourier-transform infrared (FTIR) spectroscopy, and gas chromatography coupled with mass spectrometry (GC-MS). The polyphenol-rich extracts were administered in three different concentrations for 30 days. Pain threshold, thermal hyperalgesia, edMolecules (Basel, Switzerland)Polyphenols from <i>Dichrostachys cinerea</i> Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model.PMC945791612/2020Mathieu ZBuzoianu ADParvu AEChedea VSBocsan ICKiki GAAPop RMSabin OSocaci SAFrancis TFinsia EfalsePolyphenols from <i>Dichrostachys cinerea</i> Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model.<i>Dichrostachys cinerea</i> (L.) Wigth & Arn. (DC) is widely used in traditional medicine against several inflammatory diseases, especially rheumatoid arthritis, because of its antioxidant and anti-inflammatory effects. This study aimed to characterize the polyphenol-rich DC fruit extracts and investigate the analgesic, anti-inflammatory, and antioxidant effects in a rat inflammation model induced by complete Freund's adjuvant (CFA). Water and ethanolic extracts were characterized using liquid chromatography coupled with mass spectrometry (LC-MS), Fourier-transform infrared (FTIR) spectroscopy, and gas chromatography coupled with mass spectrometry (GC-MS). The polyphenol-rich extracts were administered in three different concentrations for 30 days. Pain threshold, thermal hyperalgesia, ed2022-01-01T00:00:00Z2022 Aug2025-04-18T18:24:11.232Z2025-04-07T05:59:56.952ZS-EPMC94579163608021210.3390/molecules27175445