biostudies-literatureGoodman SPJSpitfire AssociationUniversity of New England2255-2268https://www.ebi.ac.uk/biostudies/studies/S-EPMC9458583biostudies-literatureUnknown240(9)It is unknown how hypohydration influences fine motor performance training and motor learning. Here, 30 participants (aged 19-46 years) were randomly assigned to a hypohydration (HYPO) or control (CON) group (both n = 15). Moderate hypohydration (~ 2.4% loss in body mass) was produced in HYPO via active dehydration before a 46 min fluid restricted rest period was undertaken. The conclusion of rest coincided with when CON attended the facilities. Both groups undertook a discrete sequence production task consisting of 6 training blocks, and returned ~ 300 min later to complete a delayed retention and transfer test while euhydrated. Bilateral pre-frontal cortex (PFC) haemodynamics were assessed using functional near-infrared spectroscopy throughout training and delayed learning assessments. RExperimental brain researchHypohydration alters pre-frontal cortex haemodynamics, but does not impair motor learning.PMC94585830000101840Immink MAGoodman SPJMarino FEfalseHypohydration alters pre-frontal cortex haemodynamics, but does not impair motor learning.It is unknown how hypohydration influences fine motor performance training and motor learning. Here, 30 participants (aged 19-46 years) were randomly assigned to a hypohydration (HYPO) or control (CON) group (both n = 15). Moderate hypohydration (~ 2.4% loss in body mass) was produced in HYPO via active dehydration before a 46 min fluid restricted rest period was undertaken. The conclusion of rest coincided with when CON attended the facilities. Both groups undertook a discrete sequence production task consisting of 6 training blocks, and returned ~ 300 min later to complete a delayed retention and transfer test while euhydrated. Bilateral pre-frontal cortex (PFC) haemodynamics were assessed using functional near-infrared spectroscopy throughout training and delayed learning assessments. R2022-01-01T00:00:00Z2022 Sep2026-06-03T10:40:26.308Z2025-04-19T20:35:07.085ZS-EPMC94585833588115410.1007/s00221-022-06424-5