{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiltschewskij DJ"],"funding":["Department of Health | National Health and Medical Research Council"],"pagination":["373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9458732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Psychiatric disorders such as schizophrenia are commonly associated with structural brain alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites and other biochemical traits play a causal role in many psychiatric disorders which could be mediated by changes in the cerebral cortex. Here, we leveraged publicly available genome-wide association study data to explore shared genetic architecture and evidence for causal relationships between a panel of 50 biochemical traits and measures of cortical thickness and surface area. Linkage disequilibrium score regression identified 191 genetically correlated biochemical-cortical trait pairings, with consistent representation of blood cell counts and other biomarkers such as C-reactive protein (CRP), haemoglobin and "],"journal":["Translational psychiatry"],"pubmed_title":["Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy."],"pmcid":["PMC9458732"],"funding_grant_id":["1188493","1121474","1147644"],"pubmed_authors":["Cairns MJ","Reay WR","Kiltschewskij DJ"],"additional_accession":[]},"is_claimable":false,"name":"Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.","description":"Psychiatric disorders such as schizophrenia are commonly associated with structural brain alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites and other biochemical traits play a causal role in many psychiatric disorders which could be mediated by changes in the cerebral cortex. Here, we leveraged publicly available genome-wide association study data to explore shared genetic architecture and evidence for causal relationships between a panel of 50 biochemical traits and measures of cortical thickness and surface area. Linkage disequilibrium score regression identified 191 genetically correlated biochemical-cortical trait pairings, with consistent representation of blood cell counts and other biomarkers such as C-reactive protein (CRP), haemoglobin and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-07-25T03:07:43.355Z","creation":"2025-04-06T18:08:45.816Z"},"accession":"S-EPMC9458732","cross_references":{"pubmed":["36075890"],"doi":["10.1038/s41398-022-02141-3"]}}