{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Chang Q"],"pubmed_abstract":["Ultrasensitive and selective determination of biomarkers of the bone metabolism in serum is crucial for early screening, timely treatment, and monitoring of the curative effect of osteoporosis, which is a silent disease with serious health threats. Immunoassay with a simple sensing interface and ultrahigh sensitivity is highly desirable. Herein, a simple electrochemical immunosensor is demonstrated based on gold nanoparticles (AuNPs) electrodeposited on chitosan-reduced graphene oxide (CS-G) composite modified electrode, which can achieve sensitive determination of the important biomarker of bone metabolism, bone gamma-carboxyglutamate protein (BGP). To overcome the agglomeration of graphene and introduce a biocompatible matrix with functional amino groups, CS-G is prepared and modified on"],"journal":["Frontiers in chemistry"],"pagination":["940795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9458950"],"repository":["biostudies-literature"],"pubmed_title":["Simple immunosensor for ultrasensitive electrochemical determination of biomarker of the bone metabolism in human serum."],"pmcid":["PMC9458950"],"pubmed_authors":["Chang Q","Huang J","He L","Xi F"],"additional_accession":[]},"is_claimable":false,"name":"Simple immunosensor for ultrasensitive electrochemical determination of biomarker of the bone metabolism in human serum.","description":"Ultrasensitive and selective determination of biomarkers of the bone metabolism in serum is crucial for early screening, timely treatment, and monitoring of the curative effect of osteoporosis, which is a silent disease with serious health threats. Immunoassay with a simple sensing interface and ultrahigh sensitivity is highly desirable. Herein, a simple electrochemical immunosensor is demonstrated based on gold nanoparticles (AuNPs) electrodeposited on chitosan-reduced graphene oxide (CS-G) composite modified electrode, which can achieve sensitive determination of the important biomarker of bone metabolism, bone gamma-carboxyglutamate protein (BGP). To overcome the agglomeration of graphene and introduce a biocompatible matrix with functional amino groups, CS-G is prepared and modified on","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T10:25:44.429Z","creation":"2025-04-05T10:25:44.429Z"},"accession":"S-EPMC9458950","cross_references":{"pubmed":["36092672"],"doi":["10.3389/fchem.2022.940795"]}}