biostudies-literatureUnknown10Dong ZThe exploration of novel nitrogen-rich heterocyclic building blocks is of importance in the field of energetic materials. A series of 2-(1,2,4-triazole-5-yl)-1,3,4-oxadiazole derivatives based on a new energetic skeleton have been first synthesized by a simple synthetic strategy. All three compounds are well-characterized by IR spectroscopy, NMR spectroscopy and thermal analysis. The compounds 5 and 8 are further characterized by single-crystal X-ray diffraction analysis. 8 and its salts (8a-8c) possess relative high decomposition temperature and low sensitivity, while 5 exhibits low decomposition temperature and high sensitivity. According to EXPLO5 calculation results of detonation performance, both 5 and 8 display acceptable detonaFrontiers in chemistry996812https://www.ebi.ac.uk/biostudies/studies/S-EPMC9458958biostudies-literature2-(1,2,4-triazole-5-yl)-1,3,4-oxadiazole as a novel building block for energetic materials.PMC9458958Wu ZLu GPDong ZZhang QXu Yfalse2-(1,2,4-triazole-5-yl)-1,3,4-oxadiazole as a novel building block for energetic materials.The exploration of novel nitrogen-rich heterocyclic building blocks is of importance in the field of energetic materials. A series of 2-(1,2,4-triazole-5-yl)-1,3,4-oxadiazole derivatives based on a new energetic skeleton have been first synthesized by a simple synthetic strategy. All three compounds are well-characterized by IR spectroscopy, NMR spectroscopy and thermal analysis. The compounds 5 and 8 are further characterized by single-crystal X-ray diffraction analysis. 8 and its salts (8a-8c) possess relative high decomposition temperature and low sensitivity, while 5 exhibits low decomposition temperature and high sensitivity. According to EXPLO5 calculation results of detonation performance, both 5 and 8 display acceptable detona2022-01-01T00:00:00Z20222025-04-27T01:05:31.357Z2025-04-06T18:09:29.024ZS-EPMC94589583609266510.3389/fchem.2022.996812