biostudies-literatureUnknown10Yue T<h4>Objective</h4>This study aims to reveal epidemiological features and trends of liver cancer (LC) in China.<h4>Methods</h4>We retrieved data from the Global Burden of Disease database 2019. Joinpoint regression was used to examine the temporal trend of LC. Future trends of LC were estimated using the Nordpred.<h4>Results</h4>The incidence, mortality, and disability-standardized life year (DALY) rate of LC declined in China from 1990 to 2019. Among >210,000 LC cases in 2019, the LC incidences were nearly 3.15 times higher in males than in females. LC cases and LC-associated deaths were mostly found among patients aged 65 to 69 years. The proportion of LC attributable to hepatitis B decreased over time, whereas the proportions of LC attributable to hepatitis C, alcohol use, and non-alcohoFrontiers in public health956712https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459158biostudies-literatureGender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period.PMC9459158Li GYue TCai TPourkarim MRXu MZhu HDe Clercq EfalseGender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period.<h4>Objective</h4>This study aims to reveal epidemiological features and trends of liver cancer (LC) in China.<h4>Methods</h4>We retrieved data from the Global Burden of Disease database 2019. Joinpoint regression was used to examine the temporal trend of LC. Future trends of LC were estimated using the Nordpred.<h4>Results</h4>The incidence, mortality, and disability-standardized life year (DALY) rate of LC declined in China from 1990 to 2019. Among >210,000 LC cases in 2019, the LC incidences were nearly 3.15 times higher in males than in females. LC cases and LC-associated deaths were mostly found among patients aged 65 to 69 years. The proportion of LC attributable to hepatitis B decreased over time, whereas the proportions of LC attributable to hepatitis C, alcohol use, and non-alcoho2022-01-01T00:00:00Z20222025-04-19T07:11:09.142Z2025-04-19T07:11:09.142ZS-EPMC94591583609154910.3389/fpubh.2022.956712