{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Li J"],"pubmed_abstract":["<h4>Background</h4>In China, esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of all esophageal cancer cases. Interleukin 13 (IL-13) was widely reported to play a key role in tumor progression. Our previous study reported that IL-13 was a favorable predictive marker for the overall survival of esophageal squamous cell carcinoma (ESCC) patients, but how IL-13 contributes to ESCC progression remains unknown. This study aims to explore the role of IL-13 and its underlying downstream molecular mechanisms in ESCC progression.<h4>Methods</h4>Tissue microarrays including 262 primary ESCC tumor tissues were collected and analyzed. The expression of IL-13 in ESCC tumor tissue was detected with immunohistochemistry staining (IHC). Quantitative real-time polymerase chain reaction "],"journal":["Journal of gastrointestinal oncology"],"pagination":["1571-1578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459211"],"repository":["biostudies-literature"],"pubmed_title":["Interleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells."],"pmcid":["PMC9459211"],"pubmed_authors":["Li J","Shao J","Guo Y","Guan X","Fang W","Duan C","Wang W","Lin J","Zhou Y","Wang K","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells.","description":"<h4>Background</h4>In China, esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of all esophageal cancer cases. Interleukin 13 (IL-13) was widely reported to play a key role in tumor progression. Our previous study reported that IL-13 was a favorable predictive marker for the overall survival of esophageal squamous cell carcinoma (ESCC) patients, but how IL-13 contributes to ESCC progression remains unknown. This study aims to explore the role of IL-13 and its underlying downstream molecular mechanisms in ESCC progression.<h4>Methods</h4>Tissue microarrays including 262 primary ESCC tumor tissues were collected and analyzed. The expression of IL-13 in ESCC tumor tissue was detected with immunohistochemistry staining (IHC). Quantitative real-time polymerase chain reaction ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T18:29:27.007Z","creation":"2025-04-19T18:29:27.007Z"},"accession":"S-EPMC9459211","cross_references":{"pubmed":["36092316"],"doi":["10.21037/jgo-22-559"]}}