biostudies-literatureUnknown13(4)Li J<h4>Background</h4>In China, esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of all esophageal cancer cases. Interleukin 13 (IL-13) was widely reported to play a key role in tumor progression. Our previous study reported that IL-13 was a favorable predictive marker for the overall survival of esophageal squamous cell carcinoma (ESCC) patients, but how IL-13 contributes to ESCC progression remains unknown. This study aims to explore the role of IL-13 and its underlying downstream molecular mechanisms in ESCC progression.<h4>Methods</h4>Tissue microarrays including 262 primary ESCC tumor tissues were collected and analyzed. The expression of IL-13 in ESCC tumor tissue was detected with immunohistochemistry staining (IHC). Quantitative real-time polymerase chain reaction Journal of gastrointestinal oncology1571-1578https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459211biostudies-literatureInterleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells.PMC9459211Li JShao JGuo YGuan XFang WDuan CWang WLin JZhou YWang KMa GfalseInterleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells.<h4>Background</h4>In China, esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of all esophageal cancer cases. Interleukin 13 (IL-13) was widely reported to play a key role in tumor progression. Our previous study reported that IL-13 was a favorable predictive marker for the overall survival of esophageal squamous cell carcinoma (ESCC) patients, but how IL-13 contributes to ESCC progression remains unknown. This study aims to explore the role of IL-13 and its underlying downstream molecular mechanisms in ESCC progression.<h4>Methods</h4>Tissue microarrays including 262 primary ESCC tumor tissues were collected and analyzed. The expression of IL-13 in ESCC tumor tissue was detected with immunohistochemistry staining (IHC). Quantitative real-time polymerase chain reaction 2022-01-01T00:00:00Z2022 Aug2025-04-19T18:29:27.007Z2025-04-19T18:29:27.007ZS-EPMC94592113609231610.21037/jgo-22-559