{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Wei MF"],"pubmed_abstract":["Abdominal or pelvic radiotherapy (RT) often results in small intestinal injury, such as apoptosis of epithelial cells and shortening of the villi. Atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has many biological effects including cholesterol reduction, protection from cell damage, and autophagy activation. To reduce the extent of radiotherapy- (RT-) induced enteritis, we investigated the protective effects of atorvastatin against RT-induced damage of the intestinal tract. In this study, C57BL/6 mice were randomly distributed into the following groups (<i>n</i> = 8 per group): (1) control group: mice were fed water only, (2) atorvastatin group (Ator): mice were administered atorvastatin, (3) irradiation group (IR): mice received abdominal RT, (4) Ator+IR group:"],"journal":["Oxidative medicine and cellular longevity"],"pagination":["7957255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459441"],"repository":["biostudies-literature"],"pubmed_title":["Atorvastatin Attenuates Radiotherapy-Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects."],"pmcid":["PMC9459441"],"pubmed_authors":["Wang CW","Cheng CH","Wen SY","Lin JC","Chen YH","Wei MF","Lee YH","Kuo SH"],"additional_accession":[]},"is_claimable":false,"name":"Atorvastatin Attenuates Radiotherapy-Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects.","description":"Abdominal or pelvic radiotherapy (RT) often results in small intestinal injury, such as apoptosis of epithelial cells and shortening of the villi. Atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has many biological effects including cholesterol reduction, protection from cell damage, and autophagy activation. To reduce the extent of radiotherapy- (RT-) induced enteritis, we investigated the protective effects of atorvastatin against RT-induced damage of the intestinal tract. In this study, C57BL/6 mice were randomly distributed into the following groups (<i>n</i> = 8 per group): (1) control group: mice were fed water only, (2) atorvastatin group (Ator): mice were administered atorvastatin, (3) irradiation group (IR): mice received abdominal RT, (4) Ator+IR group:","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T22:42:26.615Z","creation":"2025-04-07T10:30:06.988Z"},"accession":"S-EPMC9459441","cross_references":{"pubmed":["36092168"],"doi":["10.1155/2022/7957255"]}}