biostudies-literatureUnknown11(8)Yang H<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common subtype of lung malignancy. However, the expression of cell division cycle-associated protein-3 (<i>CDCA3</i>) and its significance in LUAD remain unclear. In this study, we investigated the functional role of <i>CDCA3</i> in LUAD through bioinformatics analysis and expected to provide a new direction for clinical treatment.<h4>Methods</h4>The expression of <i>CDCA3</i> was analyzed by online database. The association between the expression of <i>CDCA3</i> and clinical parameters with LUAD was explored in TCGA. Survival and independent prognostic analysis were performed by TCGA database and the GSE30219 and GSE31210 datasets. Furthermore, Enrichment analyses were conducted to analyze the functions of <i>CDCA3</i>. Afterward, Translational cancer research2902-2916https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459646biostudies-literaturePan-cancer analysis identifies <i>CDCA3</i> as a novel prognostic marker associated with immune infiltration in lung adenocarcinoma through bioinformatics analysis.PMC9459646Yang HWang PWei XZhang LXiang LfalsePan-cancer analysis identifies <i>CDCA3</i> as a novel prognostic marker associated with immune infiltration in lung adenocarcinoma through bioinformatics analysis.<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common subtype of lung malignancy. However, the expression of cell division cycle-associated protein-3 (<i>CDCA3</i>) and its significance in LUAD remain unclear. In this study, we investigated the functional role of <i>CDCA3</i> in LUAD through bioinformatics analysis and expected to provide a new direction for clinical treatment.<h4>Methods</h4>The expression of <i>CDCA3</i> was analyzed by online database. The association between the expression of <i>CDCA3</i> and clinical parameters with LUAD was explored in TCGA. Survival and independent prognostic analysis were performed by TCGA database and the GSE30219 and GSE31210 datasets. Furthermore, Enrichment analyses were conducted to analyze the functions of <i>CDCA3</i>. Afterward, 2022-01-01T00:00:00Z2022 Aug2025-04-18T22:40:15.568Z2025-04-07T10:22:51.598ZS-EPMC94596463609355210.21037/tcr-22-1901