{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(17)"],"submitter":["Wu YL"],"pubmed_abstract":["Coenzyme Q10 (CoQ10), a well-known antioxidant, has been explored as a treatment in several neurodegenerative diseases, but its utility in spinocerebellar ataxia type 3 (SCA3) has not been explored. Herein, the protective effect of CoQ10 was examined using a transgenic mouse model of SCA3 onset. These results demonstrated that a diet supplemented with CoQ10 significantly improved murine locomotion, revealed by rotarod and open-field tests, compared with untreated controls. Additionally, a histological analysis showed the stratification of cerebellar layers indistinguishable from that of wild-type littermates. The increased survival of Purkinje cells was reflected by the reduced abundance of TUNEL-positive nuclei and apoptosis markers of activated p53, as well as lower levels of cleaved cas"],"journal":["Nutrients"],"pagination":["3593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459709"],"repository":["biostudies-literature"],"pubmed_title":["Coenzyme Q10 Supplementation Increases Removal of the <i>ATXN3</i> Polyglutamine Repeat, Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar Ataxia Type 3."],"pmcid":["PMC9459709"],"pubmed_authors":["Cheng WL","Huang CS","Lin YS","Yen YP","Chao YC","Liu KL","Liu CS","Liu KH","Wu YL","Sun HL","Chang JC"],"additional_accession":[]},"is_claimable":false,"name":"Coenzyme Q10 Supplementation Increases Removal of the <i>ATXN3</i> Polyglutamine Repeat, Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar Ataxia Type 3.","description":"Coenzyme Q10 (CoQ10), a well-known antioxidant, has been explored as a treatment in several neurodegenerative diseases, but its utility in spinocerebellar ataxia type 3 (SCA3) has not been explored. Herein, the protective effect of CoQ10 was examined using a transgenic mouse model of SCA3 onset. These results demonstrated that a diet supplemented with CoQ10 significantly improved murine locomotion, revealed by rotarod and open-field tests, compared with untreated controls. Additionally, a histological analysis showed the stratification of cerebellar layers indistinguishable from that of wild-type littermates. The increased survival of Purkinje cells was reflected by the reduced abundance of TUNEL-positive nuclei and apoptosis markers of activated p53, as well as lower levels of cleaved cas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T07:10:15.939Z","creation":"2025-04-19T07:10:15.939Z"},"accession":"S-EPMC9459709","cross_references":{"pubmed":["36079853"],"doi":["10.3390/nu14173593"]}}