biostudies-literaturePrzybycien-Gaweda PMBiomedical Research CouncilNational Medical Research Council3535https://www.ebi.ac.uk/biostudies/studies/S-EPMC9459953biostudies-literatureUnknown14(17)There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD ± 221] vs. 510 [SD ± 290] pmol/L, <i>p</i> = 0.026), higher homocysteine (14.6 [SD ± 4.2] vs. 12.9 [SD ± 4.3], <i>p</i> = 0.018) and lower one-carbon index (Z-scores: -0.444 [SD ±NutrientsOne-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults.PMC9459953BMRC/08/1/21/19/567NMRC/1108/2007NMRC/CIRG/1409/2014Rawtaer IGao QLim WSLiew TMYap KBNg TPYap PPrzybycien-Gaweda PMGwee XLee TSChong MSCheong CYfalseOne-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults.There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD ± 221] vs. 510 [SD ± 290] pmol/L, <i>p</i> = 0.026), higher homocysteine (14.6 [SD ± 4.2] vs. 12.9 [SD ± 4.3], <i>p</i> = 0.018) and lower one-carbon index (Z-scores: -0.444 [SD ±2022-01-01T00:00:00Z2022 Aug2025-04-19T18:30:18.905Z2025-04-19T18:30:18.905ZS-EPMC94599533607979310.3390/nu14173535