biostudies-literatureUnknown17(6)De Giorgi A<h4>Introduction</h4>Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.<h4>Methods</h4>At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we eInternal and emergency medicine1651-1660https://www.ebi.ac.uk/biostudies/studies/S-EPMC9463276biostudies-literatureInsulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.PMC9463276D'Assante RCalabro PCasaretti LFrigiola ACalabro RPuzzo AMancini AFavuzzi AMRSorrentino MRMaddaloni VBruzzese DGargiulo PScarafile RDe Giorgi AMalandrino DArcopintoSalzano MAStagnaro FMGenerali TVergani ELeone MD'Andrea AMasarone DPerticone FCittadini ASciacqua AVolterrani MBruno CCastello RPassantino AGiacomazzi FSchiavo ABelfiore APaolillo SRagusa LModesti PAManfredini RMalizia GIacoviello MSuzuki TVriz ONapoli RValente PDe Vincentiis CMarra AMCimellaro ASci-Acqua ADi Segni CRaparelli VMaiello CMalinconico MCacciatore FFabbian FSalzano ACitro RAmarelli CGarofalo PRengo GBossone ELimongelli GFerrara FMatarazzo MColao ACampo MCarbone LArcopinto MT.O.S.CA. InvestigatorsGuastalamacchia EPacileo GBallotta AHeaney LMMonti MGCaliendo LRusso VFrigo ASacca LTriggiani VMattucci IFilardi PPfalseInsulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.<h4>Introduction</h4>Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.<h4>Methods</h4>At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we e2022-01-01T00:00:00Z2022 Sep2026-05-27T23:48:49.07Z2024-11-19T16:34:04.074ZS-EPMC94632763544591710.1007/s11739-022-02980-4