{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang R"],"funding":["National Natural Science Foundation of China"],"pagination":["4859-4871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9465192"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(18)"],"pubmed_abstract":["RNA-binding Motif Protein39 (RBM39) is identified as a splicing factor and transcription coactivator. Despite mounting evidence that RBM39 plays a critical role in the development of specific malignancies, no systematic pan-cancer investigation of RBM39 has been conducted. As a result, we set out to investigate RBM39's prognostic significance and putative immunological activities in 33 different cancers. Based on TCGA and CCLE, GTEx, cBioportal and HPA, we used a series of bioinformatics approaches to explore the potential oncogenic role of RBM39, including analysis of the expression of the pan-cancer species RBM39, the prognostic relationship between RBM39 expression and overall survival (OS), disease-specific survival (DSS) and progression-free interval (PFI), the relationship between RB"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Systematic pan-cancer analysis identifies RBM39 as an immunological and prognostic biomarker."],"pmcid":["PMC9465192"],"funding_grant_id":["81972165","81972845"],"pubmed_authors":["Liu N","Zhang N","Wang W","Chen X","Zhang L","Zhang R","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Systematic pan-cancer analysis identifies RBM39 as an immunological and prognostic biomarker.","description":"RNA-binding Motif Protein39 (RBM39) is identified as a splicing factor and transcription coactivator. Despite mounting evidence that RBM39 plays a critical role in the development of specific malignancies, no systematic pan-cancer investigation of RBM39 has been conducted. As a result, we set out to investigate RBM39's prognostic significance and putative immunological activities in 33 different cancers. Based on TCGA and CCLE, GTEx, cBioportal and HPA, we used a series of bioinformatics approaches to explore the potential oncogenic role of RBM39, including analysis of the expression of the pan-cancer species RBM39, the prognostic relationship between RBM39 expression and overall survival (OS), disease-specific survival (DSS) and progression-free interval (PFI), the relationship between RB","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T03:34:11.868Z","creation":"2025-04-04T03:34:11.868Z"},"accession":"S-EPMC9465192","cross_references":{"pubmed":["35989423"],"doi":["10.1111/jcmm.17517"]}}