biostudies-literatureZhang RNational Natural Science Foundation of China4859-4871https://www.ebi.ac.uk/biostudies/studies/S-EPMC9465192biostudies-literatureUnknown26(18)RNA-binding Motif Protein39 (RBM39) is identified as a splicing factor and transcription coactivator. Despite mounting evidence that RBM39 plays a critical role in the development of specific malignancies, no systematic pan-cancer investigation of RBM39 has been conducted. As a result, we set out to investigate RBM39's prognostic significance and putative immunological activities in 33 different cancers. Based on TCGA and CCLE, GTEx, cBioportal and HPA, we used a series of bioinformatics approaches to explore the potential oncogenic role of RBM39, including analysis of the expression of the pan-cancer species RBM39, the prognostic relationship between RBM39 expression and overall survival (OS), disease-specific survival (DSS) and progression-free interval (PFI), the relationship between RBJournal of cellular and molecular medicineSystematic pan-cancer analysis identifies RBM39 as an immunological and prognostic biomarker.PMC94651928197216581972845Liu NZhang NWang WChen XZhang LZhang RLiu WfalseSystematic pan-cancer analysis identifies RBM39 as an immunological and prognostic biomarker.RNA-binding Motif Protein39 (RBM39) is identified as a splicing factor and transcription coactivator. Despite mounting evidence that RBM39 plays a critical role in the development of specific malignancies, no systematic pan-cancer investigation of RBM39 has been conducted. As a result, we set out to investigate RBM39's prognostic significance and putative immunological activities in 33 different cancers. Based on TCGA and CCLE, GTEx, cBioportal and HPA, we used a series of bioinformatics approaches to explore the potential oncogenic role of RBM39, including analysis of the expression of the pan-cancer species RBM39, the prognostic relationship between RBM39 expression and overall survival (OS), disease-specific survival (DSS) and progression-free interval (PFI), the relationship between RB2022-01-01T00:00:00Z2022 Sep2025-04-04T03:34:11.868Z2025-04-04T03:34:11.868ZS-EPMC94651923598942310.1111/jcmm.17517