biostudies-literatureUnknown13Zhong H<b>Background:</b> The SERPINH1 gene plays a vital part in tumorigenesis and development, whereas its potential as an immunotherapy target is still unknown. Hence, this research aimed to probe the roles of SERPINH1 in human tumors. <b>Method:</b> Using The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) database, Oncomine, and SangerBox software, the pan-cancer expression of SERPINH1 and its correlation were systematically analyzed. SERPINH1 protein information was detected by the Human Protein Atlas (HPA) database and STRING database. The genomic alterations of SERPINH1 were studied using the c-BioPortal database. The influence of SERPINH1 on prognosis was analyzed using Kaplan-Meier plotter. The R package "clusterProfiler" was used for enrichment analysis to detect the roleFrontiers in genetics900495https://www.ebi.ac.uk/biostudies/studies/S-EPMC9465257biostudies-literaturePrognostic and immunological role of SERPINH1 in pan-cancer.PMC9465257Liu YHuang XZhong HWei XTang WWang ZMo XfalsePrognostic and immunological role of SERPINH1 in pan-cancer.<b>Background:</b> The SERPINH1 gene plays a vital part in tumorigenesis and development, whereas its potential as an immunotherapy target is still unknown. Hence, this research aimed to probe the roles of SERPINH1 in human tumors. <b>Method:</b> Using The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) database, Oncomine, and SangerBox software, the pan-cancer expression of SERPINH1 and its correlation were systematically analyzed. SERPINH1 protein information was detected by the Human Protein Atlas (HPA) database and STRING database. The genomic alterations of SERPINH1 were studied using the c-BioPortal database. The influence of SERPINH1 on prognosis was analyzed using Kaplan-Meier plotter. The R package "clusterProfiler" was used for enrichment analysis to detect the role2022-01-01T00:00:00Z20222026-06-20T03:23:41.114Z2025-02-19T00:47:33.274ZS-EPMC94652573610510610.3389/fgene.2022.900495