{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(5)"],"submitter":["Tan L"],"pubmed_abstract":["Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by inactivating mutations in <i>TSC1</i> or <i>TSC2</i>.Patients with TSC often require organ transplantation after organ failure. TSC1 serves as an important control node in immune cell development and responses; however, its effect on T cells in transplant immunity has not yet been explored. Here, we characterized the effect of TSC1 deficiency in T cells on acute allograft rejection using a mouse cardiac transplantation model. We observed compromised allograft survival in mice with TSC1-deficient T cells. Notably, the allografts in mice transferred with TSC1-deficient CD8<sup>+</sup>T cells showed accelerated acute allograft rejection. TSC1 deficiency triggered the increased accumulation of CD8<sup>+</sup> T cells i"],"journal":["Aging and disease"],"pagination":["1562-1575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9466980"],"repository":["biostudies-literature"],"pubmed_title":["Absence of TSC1 Accelerates CD8<sup>+</sup> T cell-mediated Acute Cardiac Allograft Rejection."],"pmcid":["PMC9466980"],"pubmed_authors":["Tan L","Zhang Z","Xie X","Liang Z","Wang H","Lan G","Hou Y","Zhao Y","Xu Y","Tian Q"],"additional_accession":[]},"is_claimable":false,"name":"Absence of TSC1 Accelerates CD8<sup>+</sup> T cell-mediated Acute Cardiac Allograft Rejection.","description":"Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by inactivating mutations in <i>TSC1</i> or <i>TSC2</i>.Patients with TSC often require organ transplantation after organ failure. TSC1 serves as an important control node in immune cell development and responses; however, its effect on T cells in transplant immunity has not yet been explored. Here, we characterized the effect of TSC1 deficiency in T cells on acute allograft rejection using a mouse cardiac transplantation model. We observed compromised allograft survival in mice with TSC1-deficient T cells. Notably, the allografts in mice transferred with TSC1-deficient CD8<sup>+</sup>T cells showed accelerated acute allograft rejection. TSC1 deficiency triggered the increased accumulation of CD8<sup>+</sup> T cells i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-21T18:59:04.039Z","creation":"2025-04-05T17:25:50.375Z"},"accession":"S-EPMC9466980","cross_references":{"pubmed":["36186130"],"doi":["10.14336/AD.2022.0224"]}}