biostudies-literatureUnknown13(5)Tan LTuberous sclerosis complex (TSC) is an autosomal dominant disease caused by inactivating mutations in TSC1 or TSC2.Patients with TSC often require organ transplantation after organ failure. TSC1 serves as an important control node in immune cell development and responses; however, its effect on T cells in transplant immunity has not yet been explored. Here, we characterized the effect of TSC1 deficiency in T cells on acute allograft rejection using a mouse cardiac transplantation model. We observed compromised allograft survival in mice with TSC1-deficient T cells. Notably, the allografts in mice transferred with TSC1-deficient CD8+T cells showed accelerated acute allograft rejection. TSC1 deficiency triggered the increased accumulation of CD8+ T cells iAging and disease1562-1575https://www.ebi.ac.uk/biostudies/studies/S-EPMC9466980biostudies-literatureAbsence of TSC1 Accelerates CD8+ T cell-mediated Acute Cardiac Allograft Rejection.PMC9466980Tan LZhang ZXie XLiang ZWang HLan GHou YZhao YXu YTian QfalseAbsence of TSC1 Accelerates CD8+ T cell-mediated Acute Cardiac Allograft Rejection.Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by inactivating mutations in TSC1 or TSC2.Patients with TSC often require organ transplantation after organ failure. TSC1 serves as an important control node in immune cell development and responses; however, its effect on T cells in transplant immunity has not yet been explored. Here, we characterized the effect of TSC1 deficiency in T cells on acute allograft rejection using a mouse cardiac transplantation model. We observed compromised allograft survival in mice with TSC1-deficient T cells. Notably, the allografts in mice transferred with TSC1-deficient CD8+T cells showed accelerated acute allograft rejection. TSC1 deficiency triggered the increased accumulation of CD8+ T cells i2022-01-01T00:00:00Z2022 Oct2025-04-21T18:59:04.039Z2025-04-05T17:25:50.375ZS-EPMC94669803618613010.14336/AD.2022.0224