{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu SP"],"funding":["National Institute of Environmental Health Sciences","NIBIB NIH HHS","National Institutes of Health"],"pagination":["pgac155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(4)"],"pubmed_abstract":["The uterine myometrium expands and maintains contractile quiescence before parturition. While the steroid hormone progesterone blocks labor, the role of progesterone signaling in myometrial expansion remains elusive. This study investigated the myometrial functions of the progesterone receptor, PGR. <i>Pgr</i> ablation in mouse smooth muscle leads to subfertility, oviductal embryo retention, and impaired myometrial adaptation to pregnancy. While gross morphology between mutant and control uteri are comparable, mutant uteri manifest a decrease of 76.6% oxytocin-stimulated contractility in a pseudopregnant context with a reduced expression of intracellular calcium homeostasis genes including <i>Pde5a</i> and <i>Plcb4</i>. At mid-pregnancy, the mutant myometrium exhibits discontinuous myofibe"],"journal":["PNAS nexus"],"pubmed_title":["Myometrial progesterone receptor determines a transcription program for uterine remodeling and contractions during pregnancy."],"pmcid":["PMC9470376"],"funding_grant_id":["R01 EB027099","Z1AES103311","R01EB027099","Z99-ES999999"],"pubmed_authors":["Wu SP","Peavey MC","Li X","Zhou L","Wang T","Yao ZC","Larina IV","DeMayo FJ"],"additional_accession":[]},"is_claimable":false,"name":"Myometrial progesterone receptor determines a transcription program for uterine remodeling and contractions during pregnancy.","description":"The uterine myometrium expands and maintains contractile quiescence before parturition. While the steroid hormone progesterone blocks labor, the role of progesterone signaling in myometrial expansion remains elusive. This study investigated the myometrial functions of the progesterone receptor, PGR. <i>Pgr</i> ablation in mouse smooth muscle leads to subfertility, oviductal embryo retention, and impaired myometrial adaptation to pregnancy. While gross morphology between mutant and control uteri are comparable, mutant uteri manifest a decrease of 76.6% oxytocin-stimulated contractility in a pseudopregnant context with a reduced expression of intracellular calcium homeostasis genes including <i>Pde5a</i> and <i>Plcb4</i>. At mid-pregnancy, the mutant myometrium exhibits discontinuous myofibe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T10:59:40.046Z","creation":"2025-02-19T00:13:20.708Z"},"accession":"S-EPMC9470376","cross_references":{"pubmed":["36120506"],"doi":["10.1093/pnasnexus/pgac155"]}}