{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["NICHD NIH HHS","Cancer Research UK","British Heart Foundation","Vetenskapsrådet","NIA NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","NNF Center for Basic Metabolic Research","Kjell och Märta Beijers Stiftelse","NIDDK NIH HHS","Steno Diabetes Center Copenhagen (SDCC)","Medical Research Council","National Institute for Health Research (NIHR)","NHGRI NIH HHS","NINDS NIH HHS","NCI NIH HHS","Wellcome Trust","Novo Nordisk Fonden"],"pagination":["1332-1344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(9)"],"pubmed_abstract":["Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II<sub>A</sub> muscle fibers, and possibly protection from exercise-induced muscle damage. 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Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II<sub>A</sub> muscle fibers, and possibly protection from exercise-induced muscle damage. Fi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-27T11:49:51.703Z","creation":"2024-11-14T17:52:40.619Z"},"accession":"S-EPMC9470530","cross_references":{"pubmed":["36071172"],"doi":["10.1038/s41588-022-01165-1"]}}